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Makale Tam Makale Uluslararası 2016

Spirobisnaphthalenes effectively inhibit carbonic anhydrase

Hulya Gocer, Abdulselam Aslan, İlhami Gülçin, Claudiu T. SUPURAN

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Cilt 31 · Sayı 3 · ss. 503–507 · 03.05.2016
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Özet

This study explores the correlation between human carbonic anhydrase (CA, EC 4.2.1.1) isoforms I and II (hCA I, II) and the inhibitory features of some spirobisnaphthalene derivatives. A group of spirobisnaphthalenes was synthesized and their hCA I and II inhibitory effects was investigated. The K-i values were similar for both CA isoenzymes, the compounds showing good inhibitory activity. K-i values ranged between 1.60 and 460.42 mu M for hCA I and between 0.39 and 419.42 mu M for hCA II, respectively. The spirobisnaphthalenes derivatives might be useful for designing CA inhibitors belonging to novel chemotypes compared to the highly investigated sulfonamides, sulfamates or coumarins.

Anahtar kelimeler

melatonin carbonic anhydrase DERIVATIVES enzyme inhibition TROUT ONCORHYNCHUS-MYKISS ERYTHROCYTES IN-VITRO THERAPEUTIC APPLICATIONS ISOENZYMES I enzyme purification spirobisnaphthalenes CLADOSPIRONE BISEPOXIDE ABSOLUTE-CONFIGURATION FUNGAL METABOLITES DEOXYPREUSSOMERINS

Atıf için künye

Gocer, H., Aslan, A., Gülçin, İ., & SUPURAN, C. T. (2016). Spirobisnaphthalenes effectively inhibit carbonic anhydrase. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31(3), 503–507. https://doi.org/10.3109/14756366.2015.1043298

BibTeX 
@article{gocer2016-67904,
  author = {Gocer, Hulya and Aslan, Abdulselam and Gülçin, İlhami and SUPURAN, Claudiu T.},
  title = {Spirobisnaphthalenes effectively inhibit carbonic anhydrase},
  journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
  year = {2016},
  volume = {31},
  number = {3},
  pages = {503--507},
  issn = {1475-6366},
  doi = {10.3109/14756366.2015.1043298},
  url = {https://akademik.atauni.edu.tr/yayinlar/67904-spirobisnaphthalenes-effectively-inhibit-carbonic-anhydrase}
}