A class of sulfonamides as carbonic anhydrase I and II inhibitors
Özet
Four groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO3-) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62-136.54 and 5.74-210.58nM, respectively.
Anahtar kelimeler
Atıf için künye
GOKCEN, T., Gülçin, İ., OZTURK, T., & GOREN, A. C. (2016). A class of sulfonamides as carbonic anhydrase I and II inhibitors. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31, 180–188. https://doi.org/10.1080/14756366.2016.1198900
BibTeX
@article{gokcen2016-67883,
author = {GOKCEN, Taner and Gülçin, İlhami and OZTURK, Turan and GOREN, Ahmet C.},
title = {A class of sulfonamides as carbonic anhydrase I and II inhibitors},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2016},
volume = {31},
pages = {180--188},
issn = {1475-6366},
doi = {10.1080/14756366.2016.1198900},
url = {https://akademik.atauni.edu.tr/yayinlar/67883-a-class-of-sulfonamides-as-carbonic-anhydrase-i-and-ii-inhibitors}
}