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Makale Tam Makale Uluslararası 2019

The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach

Cuneyt Caglayan, Yeliz Demır, Sefa Küçükler, Parham Taslımı, Fatih Mehmet Kandemir, İlhami Gülçin

JOURNAL OF FOOD BIOCHEMISTRY Cilt 43 · 01.02.2019
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Özet

In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. CA activities were significantly decreased in testis, liver, and heart tissues of rats given HSP, SA, SA+HSP-100, and SA+HSP-200 compared to control (p < 0.05). In liver tissue, AChE and BChE enzymes activities were significantly reduced given in all groups. In all tissues, alpha-Gly activity was reduced given in all groups. In the current study, aldose reductase enzyme activity was reduced significantly in testis, brain, and heart tissues of all groups compared to standard (p < 0.05). PON1 enzyme activity was increased significantly in kidney and liver tissues of rats HSP groups and decreased SA groups compared to control.

Anahtar kelimeler

oxidative stress ANTIOXIDANT ACTIVITY carbonic anhydrase rats IN-VIVO hesperidin BIOLOGICAL EVALUATION CRYSTAL-STRUCTURE Mannich bases INHIBITORY PROPERTIES SODIUM ARSENITE metabolic enzymes aldose reductase II INHIBITION ORANGE JUICE

Atıf için künye

Caglayan, C., Demır, Y., Küçükler, S., Taslımı, P., Kandemir, F. M., & Gülçin, İ. (2019). The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach. JOURNAL OF FOOD BIOCHEMISTRY, 43. https://doi.org/10.1111/jfbc.12720

BibTeX 
@article{caglayan2019-67880,
  author = {Caglayan, Cuneyt and Demır, Yeliz and Küçükler, Sefa and Taslımı, Parham and Kandemir, Fatih Mehmet and Gülçin, İlhami},
  title = {The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach},
  journal = {JOURNAL OF FOOD BIOCHEMISTRY},
  year = {2019},
  volume = {43},
  issn = {0145-8884},
  doi = {10.1111/jfbc.12720},
  url = {https://akademik.atauni.edu.tr/yayinlar/67880-the-effects-of-hesperidin-on-sodium-arsenite-induced-different-organ-toxicity-in}
}