Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

ÖZTAŞKIN, Necla; TASLIMI, Parham; Maraş, Ahmet; Gülçin, İlhami; Göksu, Süleyman

doi:10.1016/j.bioorg.2017.07.010

Makale Tam Makale Uluslararası 2017

Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

Necla ÖZTAŞKIN, Parham TASLIMI, Ahmet Maraş, İlhami Gülçin, Süleyman Göksu

Bioorganic Chemistry Cilt 74 · ss. 104–114 · 01.10.2017

DOI ile aç

Özet

In this study, a series of novel bromophenols were synthesized from benzoic acids and methoxylated bromophenols. The synthesized compounds were evaluated by using different bioanalytical antioxidant assays including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sul phonic acid) (ABTS(+)) radical scavenging assays. Also, reducing power of novel bromophenols were evaluated by Cu2+-Cu+ reducing, Fe3+-Fe2+ reducing and [Fe3+-(TPTZ)(2)](3+)-[Fe2+-(TPTZ)(2)](2+) reducing and ferrous ions (Fe2+) chelating abilities. The compounds demonstrate powerful antioxidant activities when compared to standard antioxidant molecules of alpha-tocopherol, trolox, butylated hydroxyanisole (BHA), and butylated hydroxytoluene (BHT). Also in the last part of this studies novel bromophenols were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II (hCA I and hCA II) isoenzymes. The newly synthesized bromophenols showed Ki values in a range of 6.78 +/- 0.68 to 126.07 +/- 35.6 nM against hCA I, 4.32 +/- 0.23 to 72.25 +/- 12.94 nM against hCA II, 4.60 +/- 1.15 to 38.13 +/- 5.91 nM against AChE and 7.36 +/- 1.31 to 29.38 +/- 3.68 nM against BChE. (C) 2017 Elsevier Inc. All rights reserved.

Anahtar kelimeler

oxidative stress ANTIOXIDANT ACTIVITY carbonic anhydrase phenolic compounds Acetylcholinesterase Butyrylcholinesterase ERYTHROCYTES IN-VITRO ISOZYMES I BIOLOGICAL EVALUATION POLYPHENOL CONTENT BROMOPHENOLS INCLUDING NATURAL-PRODUCTS RADICAL SCAVENGING ACTIVITY ISOENZYMES HCA I POTENT INHIBITOR

Atıf için künye

ÖZTAŞKIN, N., TASLIMI, P., Maraş, A., Gülçin, İ., & Göksu, S. (2017). Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Bioorganic Chemistry, 74, 104–114. https://doi.org/10.1016/j.bioorg.2017.07.010

BibTeX

@article{oztaskin2017-67861,
  author = {ÖZTAŞKIN, Necla and TASLIMI, Parham and Maraş, Ahmet and Gülçin, İlhami and Göksu, Süleyman},
  title = {Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions},
  journal = {Bioorganic Chemistry},
  year = {2017},
  volume = {74},
  pages = {104--114},
  issn = {0045-2068},
  doi = {10.1016/j.bioorg.2017.07.010},
  url = {https://akademik.atauni.edu.tr/yayinlar/67861-novel-antioxidant-bromophenols-with-acetylcholinesterase-butyrylcholinesterase}
}