A novel ag-n-heterocyclic carbene complex bearing the hydroxyethyl ligand: Synthesis, characterization, crystal and spectral structures and bioactivity properties

AKTAŞ, AYDIN; Celepci, Duygu Barut; GÖK, YETKİN; Taslimi, Parham; Akincioglu, Hulya; Gülçin, İlhami

doi:10.3390/cryst10030171

Makale Tam Makale Uluslararası 2020

A novel ag-n-heterocyclic carbene complex bearing the hydroxyethyl ligand: Synthesis, characterization, crystal and spectral structures and bioactivity properties

AYDIN AKTAŞ, Duygu Barut Celepci, YETKİN GÖK, Parham Taslimi, Hulya Akincioglu, İlhami Gülçin

Crystals Cilt 10 · Sayı 3 · 01.03.2020

DOI ile aç

Özet

In this study, a novel silver N-heterocyclic carbene (Ag-NHC) complex bearing hydroxyethyl substituent has been synthesized from the hydroxyethyl-substituted benzimidazolium salt and silver oxide by using in-situ deprotonation method. A structure of the Ag-NHC complex was characterized by using UV-Vis, FTIR, H-1-NMR and C-13-NMR spectroscopies and elemental analysis techniques. Also, the crystal structure of the novel complex was determined by single-crystal X-ray diffraction method. In this paper, compound 1 showed excellent inhibitory effects against some metabolic enzymes. This complex had Ki of 1.14 0.26 mu M against human carbonic anhydrase I (hCA I), 1.88 +/- 0.20 mu M against human carbonic anhydrase II (hCA I), and 10.75 +/- 2.47 mu M against alpha-glycosidase, respectively. On the other hand, the Ki value was found as 25.32 +/- 3.76 mu M against acetylcholinesterase (AChE) and 41.31 +/- 7.42 mu M against butyrylcholinesterase (BChE), respectively. These results showed that the complex had drug potency against some diseases related to using metabolic enzymes.

Anahtar kelimeler

IN-VITRO carbonic anhydrase antioxidant Acetylcholinesterase Butyrylcholinesterase enzyme inhibition CRYSTAL-STRUCTURE 1ST SYNTHESIS alpha-glycosidase INHIBITORY PROPERTIES Catalytic activity N-heterocyclic carbene PRECURSORS SYNTHESIS NHC PRECURSORS

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

AKTAŞ, A., Celepci, D. B., GÖK, Y., Taslimi, P., Akincioglu, H., & Gülçin, İ. (2020). A novel ag-n-heterocyclic carbene complex bearing the hydroxyethyl ligand: Synthesis, characterization, crystal and spectral structures and bioactivity properties. Crystals, 10(3). https://doi.org/10.3390/cryst10030171

BibTeX

@article{aktas2020-67857,
  author = {AKTAŞ, AYDIN and Celepci, Duygu Barut and GÖK, YETKİN and Taslimi, Parham and Akincioglu, Hulya and Gülçin, İlhami},
  title = {A novel ag-n-heterocyclic carbene complex bearing the hydroxyethyl ligand: Synthesis, characterization, crystal and spectral structures and bioactivity properties},
  journal = {Crystals},
  year = {2020},
  volume = {10},
  number = {3},
  issn = {2073-4352},
  doi = {10.3390/cryst10030171},
  url = {https://akademik.atauni.edu.tr/yayinlar/67857-a-novel-ag-n-heterocyclic-carbene-complex-bearing-the-hydroxyethyl-ligand}
}