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Makale Tam Makale Uluslararası 2017

Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes

ÜMİT MUHAMMET KOÇYİĞİT, Parham TASLIMI, HAYREDDİN GEZEGEN, İlhami Gülçin, Mustafa Ceylan

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 31 · Sayı 9 · 01.09.2017
DOI ile aç

Özet

Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ailments such as dementia and vascular dementia with Lewy bodies reduce cholinergic activity in the important areas involved in cognition and memory. Prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (AChE). These six-membered carbocycles showed nice inhibitory action against AChE and human carbonic anhydrase (hCA) II and I isoforms. The hCA I, II, and AChE were efficiently inhibited by these molecules, with K-i values in the range of 6.70-35.85nM for hCA I, 18.77-60.84nM for hCA II, and 0.74-4.60 for AChE, respectively.

Anahtar kelimeler

ANTIOXIDANT ACTIVITY carbonic anhydrase Acetylcholinesterase Butyrylcholinesterase SULFONAMIDE DERIVATIVES ENZYME-ACTIVITY VITRO Mannich bases XII ISOENZYMES HCA I ESTERASE ISOZYME-I domino reactions enzyme inhibition pentasubstituted cyclohexanol

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

KOÇYİĞİT, Ü. M., TASLIMI, P., GEZEGEN, H., Gülçin, İ., & Ceylan, M. (2017). Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 31(9). https://doi.org/10.1002/jbt.21938

BibTeX 
@article{kocyigit2017-67843,
  author = {KOÇYİĞİT, ÜMİT MUHAMMET and TASLIMI, Parham and GEZEGEN, HAYREDDİN and Gülçin, İlhami and Ceylan, Mustafa},
  title = {Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2017},
  volume = {31},
  number = {9},
  issn = {1095-6670},
  doi = {10.1002/jbt.21938},
  url = {https://akademik.atauni.edu.tr/yayinlar/67843-evaluation-of-acetylcholinesterase-and-carbonic-anhydrase-inhibition-profiles-of}
}