Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties

AKTAŞ, AYDIN; Celepci, Duygu Barut; KAYA, Ruya; TASLIMI, Parham; GÖK, YETKİN; Aygun, Muhittin; Gülçin, İlhami

doi:10.1016/j.poly.2018.11.048

Makale Tam Makale Uluslararası 2019

Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties

AYDIN AKTAŞ, Duygu Barut Celepci, Ruya KAYA, Parham TASLIMI, YETKİN GÖK, Muhittin Aygun, İlhami Gülçin

POLYHEDRON Cilt 159 · ss. 345–354 · 01.02.2019

DOI ile aç

Özet

This study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a-i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation (PEPPSI) complexes and morpholine. The new complexes were characterized by spectroscopy (IR, H-1 and C-13 NMR) techniques. Also, the crystal structures of lb and if were obtained by utilizing the single-crystal X-ray diffraction method. The synthesized compounds in this study were investigated for their inhibition action against equin serum butyrylcholinesterase (BChE) and Electrophorus electricus acetylcholinesterase (AChE) as the capability drug aims for Alzheimer's disease (AD). These novel morpholine liganded Pd-based N-heterocyclic complexes were good inhibitors of BChE, alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and AChE, with K-i values in the range of 10.77 +/- 1.01-45.86 +/- 5.65 mu M for hCA I, 25.42 +/- 5.18-57.82 +/- 3.01 mu M for hCA II, 12.26 +/- 3.32-50.36 +/- 6.19 mu M for a-glycosidase, 9.97 +/- 1.26-60.75 +/- 15.98 M for BChE, and 10.28 1.55-30.12 3.22 M for AChE. The inhibition of the alpha-glycosidase enzyme, an important carbohydrate hydrolyzing catalyst, could be used as one of the efficient methodologies in both treating and preventing diabetes by controlling the suppressing postprandial hyperglycemia and postprandial glucose amounts. (C) 2018 Elsevier Ltd. All rights reserved.

Anahtar kelimeler

IN-VITRO carbonic anhydrase antioxidant X-RAY-DIFFRACTION alpha-glucosidase DERIVATIVES Acetylcholinesterase enzyme inhibition ISOENZYMES I Catalytic activity METAL-COMPLEXES ANHYDRASE INHIBITORY PROPERTIES POTENT CARBONIC-ANHYDRASE morpholine N-Heterocyclic carbene complex

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

AKTAŞ, A., Celepci, D. B., KAYA, R., TASLIMI, P., GÖK, Y., Aygun, M., & Gülçin, İ. (2019). Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties. POLYHEDRON, 159, 345–354. https://doi.org/10.1016/j.poly.2018.11.048

BibTeX

@article{aktas2019-67820,
  author = {AKTAŞ, AYDIN and Celepci, Duygu Barut and KAYA, Ruya and TASLIMI, Parham and GÖK, YETKİN and Aygun, Muhittin and Gülçin, İlhami},
  title = {Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties},
  journal = {POLYHEDRON},
  year = {2019},
  volume = {159},
  pages = {345--354},
  issn = {0277-5387},
  doi = {10.1016/j.poly.2018.11.048},
  url = {https://akademik.atauni.edu.tr/yayinlar/67820-novel-morpholine-liganded-pd-based-n-heterocyclic-carbene-complexes-synthesis}
}