Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
Özet
A series of substituted pyrazole compounds (1-8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1-8 and 9a, b) were emerged as effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II) and acetylcholinesterase (AChE) enzymes with Ki values in the range of 1.03 +/- 0.23-22.65 +/- 5.36 mu M for hCA I, 1.82 +/- 0.30-27.94 +/- 4.74 mu M for hCA II, and 48.94 +/- 9.63-116.05 +/- 14.95 mu M for AChE, respectively. Docking studies were performed for the most active compounds, 2 and 5, and binding mode between the compounds and the receptors were determined.
Anahtar kelimeler
Atıf için künye
TÜRKAN, F., ÇETİN, A., Taslimi, P., KARAMAN, M., & Gülçin, İ. (2019). Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors. Bioorganic Chemistry, 86, 420–427. https://doi.org/10.1016/j.bioorg.2019.02.013
BibTeX
@article{turkan2019-67818,
author = {TÜRKAN, FİKRET and ÇETİN, ADNAN and Taslimi, Parham and KARAMAN, MUHAMMET and Gülçin, İlhami},
title = {Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors},
journal = {Bioorganic Chemistry},
year = {2019},
volume = {86},
pages = {420--427},
issn = {0045-2068},
doi = {10.1016/j.bioorg.2019.02.013},
url = {https://akademik.atauni.edu.tr/yayinlar/67818-synthesis-biological-evaluation-and-molecular-docking-of-novel-pyrazole}
}