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Makale Tam Makale Uluslararası 2017

The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study

Parham TASLIMI, Cuneyt Caglayan, İlhami Gülçin

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 31 · Sayı 12 · 01.12.2017
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Özet

Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), -glucosidase (-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of -glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 3.70 +/- 0.92-79.66 +/- 20.81nM against hCA I, 2.98 +/- 0.33-84.88 +/- 40.32nM against hCA II, 4.93 +/- 2.01-593.60 +/- 134.74nM against -Gly, 0.52 +/- 0.18-46.80 +/- 17.15nM against AChE, and 1.25 +/- 0.22-32.08 +/- 2.68 against BChE.

Anahtar kelimeler

IN-VITRO ANTIOXIDANT ACTIVITY carbonic anhydrase phenolic compounds alpha-glucosidase DERIVATIVES Acetylcholinesterase Butyrylcholinesterase ISOENZYMES I Mannich bases α-glycosidase POLYPHENOL CONTENTS PROFILES ESTERASE-ACTIVITIES GLUCOSIDASE INHIBITORY-ACTIVITIES

Atıf için künye

TASLIMI, P., Caglayan, C., & Gülçin, İ. (2017). The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 31(12). https://doi.org/10.1002/jbt.21995

BibTeX 
@article{taslimi2017-67812,
  author = {TASLIMI, Parham and Caglayan, Cuneyt and Gülçin, İlhami},
  title = {The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2017},
  volume = {31},
  number = {12},
  issn = {1095-6670},
  doi = {10.1002/jbt.21995},
  url = {https://akademik.atauni.edu.tr/yayinlar/67812-the-impact-of-some-natural-phenolic-compounds-on-carbonic-anhydrase}
}