Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors

AKINCIOGLU, Akin; AKBABA, Yusuf; GOCER, Hulya; Göksu, Süleyman; Gülçin, İlhami; Supuran, Claudiu T.

doi:10.1016/j.bmc.2013.01.019

Makale Tam Makale Uluslararası 2013

Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors

Akin AKINCIOGLU, Yusuf AKBABA, Hulya GOCER, Süleyman Göksu, İlhami Gülçin, Claudiu T. Supuran

BIOORGANIC & MEDICINAL CHEMISTRY Cilt 21 · Sayı 6 · ss. 1379–1385 · 15.03.2013

DOI ile aç

Özet

Sulfamides represent an important class of biologically active compounds. A series of novel sulfamides were synthesized from 1-aminoindanes, 1-aminotetralin, 2-aminoindanes and 2-aminotetralin via the reactions of free amines, benzyl alcohol and chlorosulfonyl isocyanate (CSI) followed by hydrogenolysis of the obtained sulfamoylcarbamates. Carbonic anhydrase (CA, EC 4.2.1.1) inhibitory effects of the new sulfamides have been investigated. The human (h) isozymes hCA I and hCA II have been investigated in this study by using an esterase assay with 4-nitrophenyl acetate as substrate. The new sulfamides showed inhibition constants in the micro-submicromolar range, with one compound (N-(indane-1-yl) sulfamide) showing a K-i of 0.45 mu M against hCA I and of 1.07 mu M against hCA II. (C) 2013 Elsevier Ltd. All rights reserved.

Anahtar kelimeler

VIVO melatonin carbonic anhydrase INHIBITORS phenolic compounds ERYTHROCYTES IN-VITRO ENZYME-ACTIVITY ISOZYMES I PURIFICATION BINDING sulfamide LACTOPEROXIDASE ENZYME Aminoindane Aminotetralin DANTROLENE SODIUM

Atıf için künye

AKINCIOGLU, A., AKBABA, Y., GOCER, H., Göksu, S., Gülçin, İ., & Supuran, C. T. (2013). Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY, 21(6), 1379–1385. https://doi.org/10.1016/j.bmc.2013.01.019

BibTeX

@article{akincioglu2013-67809,
  author = {AKINCIOGLU, Akin and AKBABA, Yusuf and GOCER, Hulya and Göksu, Süleyman and Gülçin, İlhami and Supuran, Claudiu T.},
  title = {Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors},
  journal = {BIOORGANIC & MEDICINAL CHEMISTRY},
  year = {2013},
  volume = {21},
  number = {6},
  pages = {1379--1385},
  issn = {0968-0896},
  doi = {10.1016/j.bmc.2013.01.019},
  url = {https://akademik.atauni.edu.tr/yayinlar/67809-novel-sulfamides-as-potential-carbonic-anhydrase-isoenzymes-inhibitors}
}