Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

OZBEY, Fadime; TASLIMI, Parham; Gülçin, İlhami; Maraş, Ahmet; Göksu, Süleyman; Supuran, Claudiu T.

doi:10.1080/14756366.2016.1189422

Makale Tam Makale Uluslararası 2016

Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

Fadime OZBEY, Parham TASLIMI, İlhami Gülçin, Ahmet Maraş, Süleyman Göksu, Claudiu T. Supuran

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Cilt 31 · ss. 79–85 · 01.12.2016

DOI ile aç

Özet

A series of diaryl ethers were synthesized and their human (h) carbonic anhydrase (CA) isoenzymes hCA I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory actions were investigated. The new compounds were synthesized from the corresponding phenols and bromobenzenes via the Ullmann reaction, by using dipicolinic acid as a copper (I) complexing ligand. hCA I and II were inhibited with K(i)s in the low nanomolar range of 102.01-127.13nM against hCA I, and of 73.71-113.40nM against hCA II, whereas the inhibition constants against AChE were of 15.35-18.34nM and against BChE in the range of 9.07-22.90nM. The CA inhibition mechanism with these ethers is unknown, but may be similar to that of aryl methyl ethers investigated earlier by computational approaches.

Anahtar kelimeler

VIVO carbonic anhydrase antioxidant Acetylcholinesterase Butyrylcholinesterase enzyme inhibition TROUT ONCORHYNCHUS-MYKISS ERYTHROCYTES IN-VITRO SULFONAMIDE DERIVATIVES ENZYME-ACTIVITY ISOZYMES I BIOLOGICAL EVALUATION ISOENZYMES HCA I diaryl ethers BROMOPHENOL DERIVATIVES

Atıf için künye

OZBEY, F., TASLIMI, P., Gülçin, İ., Maraş, A., Göksu, S., & Supuran, C. T. (2016). Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31, 79–85. https://doi.org/10.1080/14756366.2016.1189422

BibTeX

@article{ozbey2016-67808,
  author = {OZBEY, Fadime and TASLIMI, Parham and Gülçin, İlhami and Maraş, Ahmet and Göksu, Süleyman and Supuran, Claudiu T.},
  title = {Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions},
  journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
  year = {2016},
  volume = {31},
  pages = {79--85},
  issn = {1475-6366},
  doi = {10.1080/14756366.2016.1189422},
  url = {https://akademik.atauni.edu.tr/yayinlar/67808-synthesis-of-diaryl-ethers-with-acetylcholinesterase-butyrylcholinesterase-and}
}