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Makale Tam Makale Uluslararası 2017

Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes

Parham TASLIMI, İlhami Gülçin

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 31 · Sayı 10 · 01.10.2017
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Özet

-Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as -glycosidase and -amylase inhibitors. The phenolic compounds investigated in this study have been used as antidiabetic common medicines. This paper aimed to consider their capability to inhibit -amylase and -glycosidase, two significant enzymes defined in serum glucose adjustment. These examination recorded impressive inhibition profiles with IC50 values in the range of 137.36-737.23nM against -amylase and 29.01-157.96nM against -glycosidase.

Anahtar kelimeler

ACID IDENTIFICATION ANTIOXIDANT ACTIVITY phenolic compounds α-amylase Acetylcholinesterase enzyme inhibition EXTRACT POLYPHENOL CONTENT α-glycosidase ANTIRADICAL ACTIVITIES CHIONANTHUS-VIRGINICUS L. ALPHA-GLUCOSIDASE INHIBITORS HRMS-SPE-NMR

Atıf için künye

TASLIMI, P., & Gülçin, İ. (2017). Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 31(10). https://doi.org/10.1002/jbt.21956

BibTeX 
@article{taslimi2017-67789,
  author = {TASLIMI, Parham and Gülçin, İlhami},
  title = {Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2017},
  volume = {31},
  number = {10},
  issn = {1095-6670},
  doi = {10.1002/jbt.21956},
  url = {https://akademik.atauni.edu.tr/yayinlar/67789-antidiabetic-potential-in-vitro-inhibition-effects-of-some-natural-phenolic}
}