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Makale Tam Makale Uluslararası 2019

The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

Parham Taslımı, Fatih Mehmet Kandemir, Yeliz Demır, Mustafa İleritürk, Yusuf Temel, Cuneyt Caglayan, İlhami Gülçin

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 33 · Sayı 6 · 01.06.2019
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Özet

Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, alpha-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used. The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity.

Anahtar kelimeler

oxidative stress INFLAMMATION ANTIOXIDANT ACTIVITY rats IN-VIVO Acetylcholinesterase Butyrylcholinesterase CRYSTAL-STRUCTURE WISTAR RATS BROMOPHENOLS ENZYME-ACTIVITIES Chrysin POTENT CARBONIC-ANHYDRASE metabolic enzymes ALPHA-GLUCOSIDASE INHIBITORS cyclophosphamide

Atıf için künye

Taslımı, P., Kandemir, F. M., Demır, Y., İleritürk, M., Temel, Y., Caglayan, C., & Gülçin, İ. (2019). The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 33(6). https://doi.org/10.1002/jbt.22313

BibTeX 
@article{taslimi2019-67788,
  author = {Taslımı, Parham and Kandemir, Fatih Mehmet and Demır, Yeliz and İleritürk, Mustafa and Temel, Yusuf and Caglayan, Cuneyt and Gülçin, İlhami},
  title = {The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2019},
  volume = {33},
  number = {6},
  issn = {1095-6670},
  doi = {10.1002/jbt.22313},
  url = {https://akademik.atauni.edu.tr/yayinlar/67788-the-antidiabetic-and-anticholinergic-effects-of-chrysin-on-cyclophosphamide}
}