Atatürk Üniversitesi Atatürk Üniversitesi
Ara
Yayınlara dön
Makale Tam Makale Uluslararası 2016 Açık erişimli

The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates

Leyla Polat Kose, İlhami Gülçin, Alper Yıldırım, Ufuk Atmaca, Murat Çelik, Saleh H. Alwasel, Claudiu T. Supuran

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Cilt 31 · Sayı 6 · ss. 1248–1253 · 01.01.2016
DOI ile aç

Özet

The carbonic anhydrases (CAs, EC 4.2.1.1) represent a superfamily of widespread enzymes, which catalyze a crucial biochemical reaction, the reversible hydration of carbon dioxide to bicarbonate and protons. Human CA isoenzymes I and II (hCA I and hCA II) are ubiquitous cytosolic isoforms. In this study, a series of hydroperoxides, alcohols, and acetates were tested for the inhibition of the cytosolic hCA I and II isoenzymes. These compounds inhibited both hCA isozymes in the low nanomolar ranges. These compounds were good hCA I inhibitors (K(i)s in the range of 24.93-97.99 nM) and hCA II inhibitors (K(i)s in the range of 26.04-68.56 nM) compared to acetazolamide as CA inhibitor (K-i: 34.50nM for hCA I and K-i: 28.93nM for hCA II).

Anahtar kelimeler

ANTIOXIDANT ACTIVITY carbonic anhydrase phenolic compounds enzyme inhibition TROUT ONCORHYNCHUS-MYKISS SULFONAMIDE DERIVATIVES ISOFORMS I ERYTHROCYTE ISOZYMES I alcohol enzyme purification BIOCHEMICAL-CHARACTERIZATION ACETATE BRASSICA-OLERACEA L. ACETYLCHOLINE ESTERASE INHIBITORS LACTOPEROXIDASE ENZYME hydroperoxide

Atıf için künye

Kose, L. P., Gülçin, İ., Yıldırım, A., Atmaca, U., Çelik, M., Alwasel, S. H., & Supuran, C. T. (2016). The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 31(6), 1248–1253. https://doi.org/10.3109/14756366.2015.1120723

BibTeX 
@article{kose2016-67784,
  author = {Kose, Leyla Polat and Gülçin, İlhami and Yıldırım, Alper and Atmaca, Ufuk and Çelik, Murat and Alwasel, Saleh H. and Supuran, Claudiu T.},
  title = {The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates},
  journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
  year = {2016},
  volume = {31},
  number = {6},
  pages = {1248--1253},
  issn = {1475-6366},
  doi = {10.3109/14756366.2015.1120723},
  url = {https://akademik.atauni.edu.tr/yayinlar/67784-the-human-carbonic-anhydrase-isoenzymes-i-and-ii-inhibitory-effects-of-some}
}