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Makale Tam Makale Uluslararası 2016

Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines

Kadir Aksu, Bunyamin Ozgeris, Parham TASLIMI, Ali NADERI, İlhami Gülçin, Süleyman Göksu

Archiv der Pharmazie Cilt 349 · Sayı 12 · ss. 944–954 · 01.12.2016
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Özet

A series of ureas derived from phenethylamines were synthesized and evaluated for human carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzyme inhibitory activities and antioxidant properties. The ureas were synthesized from the reactions of substituted phenethylamines with N,N-dimethylcarbamoyl chloride; then, the synthesized compounds were converted to their corresponding phenolic derivatives via O-demethylation. hCA I and II were effectively inhibited by the newly synthesized compounds, with K-i values in the range of 0.307-0.432nM for hCA I and 0.149-0.278nM for hCA II. On the other hand, the K-i parameters of these compounds for AChE and BChE were determined in the range of 0.129-0.434 and 0.095-0.207 nM, respectively. Phenolic ureas also showed good antioxidant activities.

Anahtar kelimeler

carbonic anhydrase phenolic compounds DERIVATIVES Acetylcholinesterase Butyrylcholinesterase enzyme inhibition GLUTATHIONE-S-TRANSFERASE POLYPHENOL CONTENTS CAFFEIC ACID urea LYOPHILIZED AQUEOUS EXTRACT ANTIRADICAL ACTIVITIES ISOENZYMES HCA I POTENT INHIBITOR ESTER CAPE

Atıf için künye

Aksu, K., Ozgeris, B., TASLIMI, P., NADERI, A., Gülçin, İ., & Göksu, S. (2016). Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Archiv der Pharmazie, 349(12), 944–954. https://doi.org/10.1002/ardp.201600183

BibTeX 
@article{aksu2016-67781,
  author = {Aksu, Kadir and Ozgeris, Bunyamin and TASLIMI, Parham and NADERI, Ali and Gülçin, İlhami and Göksu, Süleyman},
  title = {Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines},
  journal = {Archiv der Pharmazie},
  year = {2016},
  volume = {349},
  number = {12},
  pages = {944--954},
  issn = {0365-6233},
  doi = {10.1002/ardp.201600183},
  url = {https://akademik.atauni.edu.tr/yayinlar/67781-antioxidant-activity-acetylcholinesterase-and-carbonic-anhydrase-inhibitory}
}