N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II
Özet
Sulfonamides represent a significant class of biologically active compounds that inhibit carbonic anhydrase (CA, EC.: 4.2.1.1) isoenzymes involved in different pathological and physiological events. Sulfonamide CA inhibitors are used therapeutically as diuretic, antiglaucoma, antiobesity and anticancer agents. A series of new sulfonamides were synthesized using imides and tosyl chloride as starting materials. These N-acylsulfonamides efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I, and II (hCA I, and II), with nanomolar range inhibition constants ranging between 36.4 +/- 6.0-254.6 +/- 18.0 and 58.3 +/- 0.6-273.3 +/- 2.5 nM, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
Anahtar kelimeler
Atıf için künye
Yıldırım, A., Atmaca, U., Keskın, A., Topal, M., Çelik, M., Gülçin, İ., & Supuran, C. T. (2015). N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II. BIOORGANIC & MEDICINAL CHEMISTRY, 23(10), 2598–2605. https://doi.org/10.1016/j.bmc.2014.12.054
BibTeX
@article{yildirim2015-67767,
author = {Yıldırım, Alper and Atmaca, Ufuk and Keskın, Ali and Topal, Meryem and Çelik, Murat and Gülçin, İlhami and Supuran, Claudiu T.},
title = {N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II},
journal = {BIOORGANIC & MEDICINAL CHEMISTRY},
year = {2015},
volume = {23},
number = {10},
pages = {2598--2605},
issn = {0968-0896},
doi = {10.1016/j.bmc.2014.12.054},
url = {https://akademik.atauni.edu.tr/yayinlar/67767-n-acylsulfonamides-strongly-inhibit-human-carbonic-anhydrase-isoenzymes-i-and-ii}
}