Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base

TASLIMI, Parham; OSMANOVA, Sabiya; Gülçin, İlhami; SARDAROVA, Sabira; FARZALIYEV, Vagif; SUJAYEV, Afsun; KAYA, Ruya; KOC, Fatma; Beydemir, Sukru; ALWASEL, Saleh H.; Küfrevioğlu, Ömer İrfan

doi:10.1002/jbt.21931

Makale Tam Makale Uluslararası 2017

Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base

Parham TASLIMI, Sabiya OSMANOVA, İlhami Gülçin, Sabira SARDAROVA, Vagif FARZALIYEV, Afsun SUJAYEV, Ruya KAYA, Fatma KOC, Sukru Beydemir, Saleh H. ALWASEL, Ömer İrfan Küfrevioğlu

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 31 · Sayı 9 · 01.09.2017

DOI ile aç

Özet

Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an important place. These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. AChE exists at high concentrations in the brain and red blood cells. BChE is an important enzyme that is plentiful in the liver, and it is released into the blood in a soluble form. They were demonstrated to have effective inhibition profiles with K-i values of 23.76-102.75nM against hCA I, 58.92-136.64nM against hCA II, 1.40-12.86nM against AChE, and 9.82-52.77nM against BChE. On the other hand, acetazolamide showed K-i value of 482.63 +/- 56.20nM against hCA I, and 1019.60 +/- 163.70nM against hCA II. Additionally, Tacrine inhibited AChE and BChE, showing K-i values of 397.03 +/- 31.66 and 210.21 +/- 15.98nM, respectively.

Anahtar kelimeler

ACID ANTIOXIDANT ACTIVITY carbonic anhydrase Acetylcholinesterase Butyrylcholinesterase enzyme inhibition SULFONAMIDE DERIVATIVES PURIFICATION VITRO Mannich bases BIOACTIVITY ACETOPHENONE PROFILES ISOENZYMES HCA I ESTERASE

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

TASLIMI, P., OSMANOVA, S., Gülçin, İ., SARDAROVA, S., FARZALIYEV, V., SUJAYEV, A., KAYA, R., KOC, F., Beydemir, S., ALWASEL, S. H., & Küfrevioğlu, Ö. İ. (2017). Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 31(9). https://doi.org/10.1002/jbt.21931

BibTeX

@article{taslimi2017-67707,
  author = {TASLIMI, Parham and OSMANOVA, Sabiya and Gülçin, İlhami and SARDAROVA, Sabira and FARZALIYEV, Vagif and SUJAYEV, Afsun and KAYA, Ruya and KOC, Fatma and Beydemir, Sukru and ALWASEL, Saleh H. and Küfrevioğlu, Ömer İrfan},
  title = {Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2017},
  volume = {31},
  number = {9},
  issn = {1095-6670},
  doi = {10.1002/jbt.21931},
  url = {https://akademik.atauni.edu.tr/yayinlar/67707-discovery-of-potent-carbonic-anhydrase-acetylcholinesterase-and}
}