Some pyrazoles derivatives: Potent carbonic anhydrase, -glycosidase, and cholinesterase enzymes inhibitors

Turkan, Fikret; Cetin, Adnan; TASLIMI, Parham; Gülçin, İlhami

doi:10.1002/ardp.201800200

Makale Tam Makale Uluslararası 2018

Some pyrazoles derivatives: Potent carbonic anhydrase, -glycosidase, and cholinesterase enzymes inhibitors

Fikret Turkan, Adnan Cetin, Parham TASLIMI, İlhami Gülçin

Archiv der Pharmazie Cilt 351 · Sayı 10 · 01.10.2018

DOI ile aç

Özet

A series of substituteed pyrazol-4-yl-diazene derivatives were found to be effective inhibitors against -glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with K-i values in the range of 33.72 +/- 7.93 to 90.56 +/- 27.52nM for -glycosidase, 1.06 +/- 0.16 to 9.83 +/- 0.74nM for hCA I, 0.68 +/- 0.12 to 7.16 +/- 1.14nM for hCA II, 44.66 +/- 10.06 to 78.34 +/- 17.83nM for AChE, and 50.36 +/- 13.88 to 88.36 +/- 20.03nM for BChE, respectively. Recently, inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances, such as diabetes, glaucoma, obesity, epilepsy, cancer, and neurodegenerative diseases.

Anahtar kelimeler

carbonic anhydrase antioxidant alpha-glucosidase Acetylcholinesterase Butyrylcholinesterase enzyme inhibition benzenesulfonamides 1ST SYNTHESIS GLUTATHIONE-S-TRANSFERASE BROMOPHENOLS PROFILES INCLUDING NATURAL-PRODUCTS substituted pyrazol-4-yl-diazene

Sürdürülebilir Kalkınma Amaçları

SKA 3: Sağlıklı Bireyler

Atıf için künye

Turkan, F., Cetin, A., TASLIMI, P., & Gülçin, İ. (2018). Some pyrazoles derivatives: Potent carbonic anhydrase, -glycosidase, and cholinesterase enzymes inhibitors. Archiv der Pharmazie, 351(10). https://doi.org/10.1002/ardp.201800200

BibTeX

@article{turkan2018-67695,
  author = {Turkan, Fikret and Cetin, Adnan and TASLIMI, Parham and Gülçin, İlhami},
  title = {Some pyrazoles derivatives: Potent carbonic anhydrase, -glycosidase, and cholinesterase enzymes inhibitors},
  journal = {Archiv der Pharmazie},
  year = {2018},
  volume = {351},
  number = {10},
  issn = {0365-6233},
  doi = {10.1002/ardp.201800200},
  url = {https://akademik.atauni.edu.tr/yayinlar/67695-some-pyrazoles-derivatives-potent-carbonic-anhydrase-glycosidase-and}
}