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Makale Tam Makale Uluslararası 2017

Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats

ÜMİT MUHAMMET KOÇYİĞİT, Ahmet Sevki Taskiran, Parham TASLIMI, AHMET YOKUŞ, Yusuf Temel, İlhami Gülçin

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY Cilt 31 · Sayı 11 · 01.11.2017
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Özet

The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in liver and kidney tissues of rats. For this purpose, four different groups, each consisting of six rats (n=6), were formed (control group, OT administered group, atosiban administered group, and both OT and atosiban administered group). The rats were necropsied 60min after intraperitoneal injection of chemicals into the rats. Liver tissues of rats were extracted. CA and AChE enzyme activities were measured for each tissue by using hydratase, esterase, and acetylcholiniodide methods. Activity values for each enzyme obtained were statistically calculated.

Anahtar kelimeler

IN-VITRO MUSCLE carbonic anhydrase Rat ENZYME-ACTIVITY PURIFICATION PROFILES ESTERASE oxytocin II INHIBITION VASOPRESSIN

Atıf için künye

KOÇYİĞİT, Ü. M., Taskiran, A. S., TASLIMI, P., YOKUŞ, A., Temel, Y., & Gülçin, İ. (2017). Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 31(11). https://doi.org/10.1002/jbt.21972

BibTeX 
@article{kocyigit2017-67668,
  author = {KOÇYİĞİT, ÜMİT MUHAMMET and Taskiran, Ahmet Sevki and TASLIMI, Parham and YOKUŞ, AHMET and Temel, Yusuf and Gülçin, İlhami},
  title = {Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats},
  journal = {JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY},
  year = {2017},
  volume = {31},
  number = {11},
  issn = {1095-6670},
  doi = {10.1002/jbt.21972},
  url = {https://akademik.atauni.edu.tr/yayinlar/67668-inhibitory-effects-of-oxytocin-and-oxytocin-receptor-antagonist-atosiban-on-the}
}