A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding

Kuzu, Burak; Tan Uygun, Meltem; Gülçin, İlhami; Mengeş, Nurettin

doi:10.1002/ardp.202100188

Makale Tam Makale Uluslararası 2021

A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding

Burak Kuzu, Meltem Tan Uygun, İlhami Gülçin, Nurettin Mengeş

Archiv der Pharmazie Cilt 354 · Sayı 10 · 01.10.2021

DOI ile aç

Özet

In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.

Anahtar kelimeler

DERIVATIVES coumarin sulfonamide ISOENZYMES I MECHANISM DOCKING imidazole CARBONIC-ANHYDRASE INHIBITION XII CLONING TARGET imidazole ring non-zinc binding SAR study ISOZYME-I

Atıf için künye

Kuzu, B., Tan Uygun, M., Gülçin, İ., & Mengeş, N. (2021). A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding. Archiv der Pharmazie, 354(10). https://doi.org/10.1002/ardp.202100188

BibTeX

@article{kuzu2021-67667,
  author = {Kuzu, Burak and Tan Uygun, Meltem and Gülçin, İlhami and Mengeş, Nurettin},
  title = {A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding},
  journal = {Archiv der Pharmazie},
  year = {2021},
  volume = {354},
  number = {10},
  issn = {0365-6233},
  doi = {10.1002/ardp.202100188},
  url = {https://akademik.atauni.edu.tr/yayinlar/67667-a-novel-class-for-carbonic-anhydrases-inhibitors-and-evaluation-of-their-non}
}