Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV

Innocenti, Alessio; Gülçin, İlhami; Scozzafava, Andrea; SUPURAN, Claudiu T.

doi:10.1016/j.bmcl.2010.07.038

Makale Tam Makale Uluslararası 2010

Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV

Alessio Innocenti, İlhami Gülçin, Andrea Scozzafava, Claudiu T. SUPURAN

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Cilt 20 · Sayı 17 · ss. 5050–5053 · 01.09.2010

DOI ile aç

Özet

A series of polyphenolic derivatives, including resveratrol, dobutamine, curcumin, catechin and silymarine were investigated for the inhibition of all the catalytically active mammalian isozymes of the metalloprotein carbonic anhydrase (CA, EC 4.2.1.1), that is, CA I-CA XV. These polyphenols effectively inhibited CAs, with K(I)s in the range of 380 nM-12.02 mu M. The various isozymes showed quite diverse inhibition profiles with these compounds, which possess scaffolds not present in other investigated CA inhibitors (CAIs). These data may lead to drug design campaigns of effective CAIs possessing a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors, based on such less investigated scaffolds. (C) 2010 Elsevier Ltd. All rights reserved.

Anahtar kelimeler

SERIES carbonic anhydrase resveratrol DERIVATIVES COUMARINS curcumin Enzyme inhibitor phenols ACTIVATORS ERYTHROCYTE ISOZYMES I POLYPHENOL SALICYLIC-ACID VITRO ANTIOXIDANT Catechin Dobutamine Silymarine Isozymes I-XV ACTIVE-SITE XIV

Atıf için künye

Innocenti, A., Gülçin, İ., Scozzafava, A., & SUPURAN, C. T. (2010). Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(17), 5050–5053. https://doi.org/10.1016/j.bmcl.2010.07.038

BibTeX

@article{innocenti2010-67665,
  author = {Innocenti, Alessio and Gülçin, İlhami and Scozzafava, Andrea and SUPURAN, Claudiu T.},
  title = {Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV},
  journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS},
  year = {2010},
  volume = {20},
  number = {17},
  pages = {5050--5053},
  issn = {0960-894X},
  doi = {10.1016/j.bmcl.2010.07.038},
  url = {https://akademik.atauni.edu.tr/yayinlar/67665-carbonic-anhydrase-inhibitors-antioxidant-polyphenols-effectively-inhibit}
}