Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials
Özet
Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K-i values in the range of 0.80 +/- 0.24-3.52 +/- 1.01 mu M for hCA I, 1.08 +/- 0.15-3.64 +/- 0.92 mu M for hCA II, 5.18 +/- 0.84-12.46 +/- 2.08 mu M for alpha-glycosidase, and 11.33 +/- 2.83-32.81 +/- 9.73 mu M for AChE, respectively.
Anahtar kelimeler
Atıf için künye
Bilgicli, H. G., Kestane, A., Taslimi, P., Karabay, O., Bytyqi-Damoni, A., Zengin, M., & Gülçin, İ. (2019). Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials. Bioorganic Chemistry, 88. https://doi.org/10.1016/j.bioorg.2019.102931
BibTeX
@article{bilgicli2019-67634,
author = {Bilgicli, Hayriye Genc and Kestane, Ali and Taslimi, Parham and Karabay, Oguz and Bytyqi-Damoni, Arlinda and Zengin, Mustafa and Gülçin, İlhami},
title = {Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials},
journal = {Bioorganic Chemistry},
year = {2019},
volume = {88},
issn = {0045-2068},
doi = {10.1016/j.bioorg.2019.102931},
url = {https://akademik.atauni.edu.tr/yayinlar/67634-novel-eugenol-bearing-oxypropanolamines-synthesis-characterization-antibacterial}
}