Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base

Buldurun, Kenan; Turan, Nevin; Bursal, Ercan; Mantarcı, Asim; Turkan, Fikret; Taslimi, Parham; Gülçin, İlhami

doi:10.1007/s11164-019-03949-3

Makale Tam Makale Uluslararası 2020

Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base

Kenan Buldurun, Nevin Turan, Ercan Bursal, Asim Mantarcı, Fikret Turkan, Parham Taslimi, İlhami Gülçin

RESEARCH ON CHEMICAL INTERMEDIATES Cilt 46 · Sayı 1 · ss. 283–297 · 01.01.2020

DOI ile aç

Özet

Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV-Vis, thermogravimetry-differential thermal analysis (TGA-DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with K-i values of 52.83 +/- 11.52 and 63.34 +/- 8.88, respectively.

Anahtar kelimeler

ANTIOXIDANT ACTIVITY carbonic anhydrase Acetylcholinesterase Molecular docking enzyme inhibition BIOLOGICAL EVALUATION ANTIMICROBIAL ACTIVITIES POLYPHENOL CONTENT DNA-BINDING X-RAY METAL-COMPLEXES DFT calculations Schiff base TRANSITION-METAL-COMPLEXES XRD analysis

Atıf için künye

Buldurun, K., Turan, N., Bursal, E., Mantarcı, A., Turkan, F., Taslimi, P., & Gülçin, İ. (2020). Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base. RESEARCH ON CHEMICAL INTERMEDIATES, 46(1), 283–297. https://doi.org/10.1007/s11164-019-03949-3

BibTeX

@article{buldurun2020-67614,
  author = {Buldurun, Kenan and Turan, Nevin and Bursal, Ercan and Mantarcı, Asim and Turkan, Fikret and Taslimi, Parham and Gülçin, İlhami},
  title = {Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base},
  journal = {RESEARCH ON CHEMICAL INTERMEDIATES},
  year = {2020},
  volume = {46},
  number = {1},
  pages = {283--297},
  issn = {0922-6168},
  doi = {10.1007/s11164-019-03949-3},
  url = {https://akademik.atauni.edu.tr/yayinlar/67614-synthesis-spectroscopic-properties-crystal-structures-antioxidant-activities-and}
}