Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts
Özet
The aim of this work was to investigate the enzyme inhibition, antioxidant activity, and phenolic compounds of Lecokia cretica (Lam.) DC. Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase enzymes were strongly inhibited by the L. cretica extracts. IC50 values for the three enzymes were found as 3.21 mg/mL, 2.1 mg/mL, and 2.07 mg/mL, respectively. Antioxidant activities were examined in both aqueous and ethanol (EtOH) extracts using CUPRAC, FRAP, and DPPH method. Also, the phenolic compounds of the endemic plant were identified and quantified by using HPLC/MS/MS. According to the results, the extracts have remarkable antioxidant activities. The most abundant phenolic acids of L. cretica in EtOH extract were determined as quinic acid (12.76 mg/kg of crude extract), chlorogenic acid (3.39 mg/kg), and malic acid (2.38 mg/kg).
Anahtar kelimeler
Atıf için künye
Aras, A., Bursal, E., Turkan, F., Tohma, H., Kilic, O., Gülçin, İ., & KÖKSAL, E. (2019). Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts. CHEMISTRY AND BIODIVERSITY, 16(10). https://doi.org/10.1002/cbdv.201900341
BibTeX
@article{aras2019-67577,
author = {Aras, Abdulmelik and Bursal, Ercan and Turkan, Fikret and Tohma, Hatice and Kilic, Omer and Gülçin, İlhami and KÖKSAL, EKREM},
title = {Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts},
journal = {CHEMISTRY AND BIODIVERSITY},
year = {2019},
volume = {16},
number = {10},
issn = {1612-1872},
doi = {10.1002/cbdv.201900341},
url = {https://akademik.atauni.edu.tr/yayinlar/67577-phytochemical-content-antidiabetic-anticholinergic-and-antioxidant-activities-of}
}