Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors

KÖKSAL, ZEYNEP; KALIN, Ramazan; Camadan, Yasemin; Usanmaz, Hande; Almaz, Zuleyha; Gülçin, İlhami; GOKCEN, Taner; GOREN, Ahmet Ceyhan; Özdemir, Hasan

doi:10.3390/molecules22060793

Makale Tam Makale Uluslararası 2017

Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors

ZEYNEP KÖKSAL, Ramazan KALIN, Yasemin Camadan, Hande Usanmaz, Zuleyha Almaz, İlhami Gülçin, Taner GOKCEN, Ahmet Ceyhan GOREN, Hasan Özdemir

MOLECULES Cilt 22 · Sayı 6 · 01.06.2017

DOI ile aç

Özet

Secondary sulfonamides (4a-8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a-8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a-8h) are effective LPO inhibitors. The K-i values of secondary sulfonamide derivatives (4a-8h) were found in the range of 1.096 x 10(-3) to 1203.83 mu M against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with K-i values of 1.096 x 10(-3) +/- 0.471 x 10(-3) mu M as non-competitive inhibition.

Anahtar kelimeler

SYSTEM DERIVATIVES enzyme inhibition PURIFICATION ENZYME carbonic anhydrase isoenzymes IX XII DOPAMINE Affinity chromatography enzyme purification Lactoperoxidase bovine milk secondary sulfonamide

Atıf için künye

KÖKSAL, Z., KALIN, R., Camadan, Y., Usanmaz, H., Almaz, Z., Gülçin, İ., GOKCEN, T., GOREN, A. C., & Özdemir, H. (2017). Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors. MOLECULES, 22(6). https://doi.org/10.3390/molecules22060793

BibTeX

@article{koksal2017-67354,
  author = {KÖKSAL, ZEYNEP and KALIN, Ramazan and Camadan, Yasemin and Usanmaz, Hande and Almaz, Zuleyha and Gülçin, İlhami and GOKCEN, Taner and GOREN, Ahmet Ceyhan and Özdemir, Hasan},
  title = {Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors},
  journal = {MOLECULES},
  year = {2017},
  volume = {22},
  number = {6},
  issn = {1420-3049},
  doi = {10.3390/molecules22060793},
  url = {https://akademik.atauni.edu.tr/yayinlar/67354-secondary-sulfonamides-as-effective-lactoperoxidase-inhibitors}
}