Antibacterial properties and carbonic anhydrase inhibition profiles of azido sulfonyl carbamate derivatives
Özet
The aim of this study was to identify inhibition of carbonic anhydrase I and II (CA I and II) isozymes
by azido sulfonyl carbamates through both in vitro and in silico approaches and also to determine the
drug-likeness properties and antibacterial activities of azido sulfonyl carbamates. Methods & Results: In
vitro inhibition and molecular docking studies of azido sulfonyl carbamate derivatives (1–4) on isozymes
were performed. Except for derivative 4, all derivatives inhibited human CA I and II. Almost all compounds
had antibacterial effects. The docking results showed that compound 3 had the best results, with binding
energy of -8.20 kcal/mol for human CA I and -8.24 kcal/mol for human CA II. Conclusion: Molecule 4
inhibited only CA I. Its usage as a potential chemotherapeutic agent specific to the CA I isozyme may be
considered.
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Anahtar kelimeler
Atıf için künye
Güller, P., Atmaca, U., Güller, U., Çalışır, U., & Dursun, F. (2021). Antibacterial properties and carbonic anhydrase inhibition profiles of azido sulfonyl carbamate derivatives. Future Medicinal Chemistry, 13(15), 1285–1299. https://doi.org/10.4155/fmc-2020-0387
BibTeX
@article{guller2021-67149,
author = {Güller, Pınar and Atmaca, Ufuk and Güller, Uğur and Çalışır, Ulaş and Dursun, Feray},
title = {Antibacterial properties and carbonic anhydrase inhibition profiles of azido sulfonyl carbamate derivatives},
journal = {Future Medicinal Chemistry},
year = {2021},
volume = {13},
number = {15},
pages = {1285--1299},
issn = {1756-8919},
doi = {10.4155/fmc-2020-0387},
url = {https://akademik.atauni.edu.tr/yayinlar/67149-antibacterial-properties-and-carbonic-anhydrase-inhibition-profiles-of-azido}
}