4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy
Özet
The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecularH-bonds. X-ray Crystallography, FT-IR, and(1)H and(13)C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.
Atıf için künye
Pesyan, N. N., Rashidnejad, H., Esmaeili, M. A., Safari, E., TUNÇ, T., Alilou, M., Safavi-Sohi, R., & Şahin, E. (2020). 4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 67(9), 1679–1695. https://doi.org/10.1002/jccs.202000057
BibTeX
@article{pesyan2020-66804,
author = {Pesyan, Nader Noroozi and Rashidnejad, Hamid and Esmaeili, Mohammad Ali and Safari, Elnaz and TUNÇ, TUNCAY and Alilou, Mostafa and Safavi-Sohi, Reihaneh and Şahin, Ertan},
title = {4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy},
journal = {JOURNAL OF THE CHINESE CHEMICAL SOCIETY},
year = {2020},
volume = {67},
number = {9},
pages = {1679--1695},
issn = {0009-4536},
doi = {10.1002/jccs.202000057},
url = {https://akademik.atauni.edu.tr/yayinlar/66804-4-methylmorpholinium-bis-thiobarbiturates-synthesis-structure-anticancer}
}