A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides
Özet
A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[ 3,4-b] quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series 9a-g was evaluated for in vitro antibacterial activity against (+ve bacteria) Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, (-ve bacterium) Escherichia coli ATCC 25922. In vitro minimum inhibitory concentration (MIC) evaluations showed that the compound 9a was effective against E. coli (MIC: 0.25 mg/mL) S. aureus (MIC: 0.25 mg/mL) and E. faecalis (MIC: 0.5 mg/mL).
Anahtar kelimeler
Atıf için künye
Largani, T. H., Imanzadeh, G., Zahri, S., Pesyan, N. N., & Şahin, E. (2017). A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides. GREEN CHEMISTRY LETTERS AND REVIEWS, 10(4), 387–392. https://doi.org/10.1080/17518253.2017.1380233
BibTeX
@article{largani2017-66748,
author = {Largani, Tahere Hosseyni and Imanzadeh, Gholamhassan and Zahri, Saber and Pesyan, Nader Noroozi and Şahin, Ertan},
title = {A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides},
journal = {GREEN CHEMISTRY LETTERS AND REVIEWS},
year = {2017},
volume = {10},
number = {4},
pages = {387--392},
issn = {1751-8253},
doi = {10.1080/17518253.2017.1380233},
url = {https://akademik.atauni.edu.tr/yayinlar/66748-a-facile-synthesis-and-antibacterial-activity-of-novel-pyrrolo34-bquinolin-23h}
}