Novel bioactive vic-dioxime ligand containing piperazine moiety: Synthesis, X-ray crystallographic studies, 2D NMR applications and complexation with Ni(II)
Özet
A new vic-dioxime ligand bearing an important pharmacophore substituent, anti-1-(4-benzylpiperazine-1-yl) phenylglyoxime (LH2) (Scheme 1), has been synthesized and its nickel(II) complex was obtained by the reaction of NiCl2 center dot 6H(2)O and the ligand. The characterization of the newly formed compounds was performed by elemental analysis, FT-IR, 1D NMR (H-1, C-13, DEPT), 2D NMR (HMBC), ESI mass-spectrometry, TG/DTA, X-ray crystallography. The antibacterial activity was also studied against Staphylococcus aureus ATCC 25923, Streptococcus mutans RSHM 676, Enterococcus faecalis ATCC 29212, Lactobacillus acidophilus RSHM 06029, Escherichia coli ATCC 25922, E. coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853. The antimicrobial test results indicated that all the compounds have mild antibacterial activity against both Gram negative and Gram positive bacterial species. (C) 2010 Elsevier Ltd. All rights reserved.
Atıf için künye
Yilmaz, A., TANER, B., DEVECİ, P., OBALI, A. Y., ARSLAN, U., Şahin, E., UÇAN, H. İ., & ÖZCAN, E. (2010). Novel bioactive vic-dioxime ligand containing piperazine moiety: Synthesis, X-ray crystallographic studies, 2D NMR applications and complexation with Ni(II). POLYHEDRON, 29(15), 2991–2998. https://doi.org/10.1016/j.poly.2010.08.006
BibTeX
@article{yilmaz2010-66718,
author = {Yilmaz, Aytek and TANER, BİLGE and DEVECİ, PERVİN and OBALI, ASLIHAN YILMAZ and ARSLAN, UĞUR and Şahin, Ertan and UÇAN, HALİL İSMET and ÖZCAN, EMİNE},
title = {Novel bioactive vic-dioxime ligand containing piperazine moiety: Synthesis, X-ray crystallographic studies, 2D NMR applications and complexation with Ni(II)},
journal = {POLYHEDRON},
year = {2010},
volume = {29},
number = {15},
pages = {2991--2998},
issn = {0277-5387},
doi = {10.1016/j.poly.2010.08.006},
url = {https://akademik.atauni.edu.tr/yayinlar/66718-novel-bioactive-vic-dioxime-ligand-containing-piperazine-moiety-synthesis-x-ray}
}