Synthesis of new hexahydro-1H-isoindole-1,3(2H)-dione derivatives from 2-ethyl/pheny1-3a,4,7,7a-tetrahydro-1H-isoindole-1,3-(2H)-dione
Özet
A new and appropriate synthesis for hexahydro-1H-isoindole-1,3(2H)-dione derivatives has been developed starting from 3-sulfolene. The epoxidation of 2-ethyl/pheny1-3a,4,7,7a-tetrahydro-1H-isoindole-1,3-(2H)-dione and then the opening of the epoxide with nucleophiles gave hexahydro-1H-isoindole-1,3(2H)-dione derivatives. Amino and triazole derivatives of hexahydro-1H-isoindole-1,3(2H)-dione were synthesized from the formed product by the opening reaction of the epoxide with sodium azide. Hydroxyl analogues were obtained from cis-hydroxylation of 2-ethyl/pheny1-3a,4,7,7atetrahydro-1H-isoindole-1,3-(2H)-dione. The hydroxyl groups were converted to acetate.
Anahtar kelimeler
Atıf için künye
Tan, A., KOÇ, B., Horasan, N., Şahin, E., & Kara, Y. (2016). Synthesis of new hexahydro-1H-isoindole-1,3(2H)-dione derivatives from 2-ethyl/pheny1-3a,4,7,7a-tetrahydro-1H-isoindole-1,3-(2H)-dione. TURKISH JOURNAL OF CHEMISTRY, 40(5), 830–840. https://doi.org/10.3906/kim-1511-66
BibTeX
@article{tan2016-66699,
author = {Tan, Ayse and KOÇ, Birgul and Horasan, Nurhan and Şahin, Ertan and Kara, Yunus},
title = {Synthesis of new hexahydro-1H-isoindole-1,3(2H)-dione derivatives from 2-ethyl/pheny1-3a,4,7,7a-tetrahydro-1H-isoindole-1,3-(2H)-dione},
journal = {TURKISH JOURNAL OF CHEMISTRY},
year = {2016},
volume = {40},
number = {5},
pages = {830--840},
issn = {1300-0527},
doi = {10.3906/kim-1511-66},
url = {https://akademik.atauni.edu.tr/yayinlar/66699-synthesis-of-new-hexahydro-1h-isoindole-132h-dione-derivatives-from-2}
}