Synthesis and paroxonase activities of novel bromophenols
Özet
Three novel bromophenols 10-12 were synthesized. Acylation of veratrole (4) with 2,3-dimethoxy benzoic acid (5) gave a kown diarylmethanone 6. Bromination of 6 with different equivalents of molecular bromine afforded new di and tribrominated compounds 7-9 which were converted to their corresponding bromophenols 10-12 via O-demethylation with BBr3. Paraoxonase-1 (PON1) was purified from human serum with approximately 42% and 3584 U x mg(-1) specific activity. The synthesized compounds 6-12 showed inhibitory effects on paraoxonase-1 (PON1) which is an organophosphate (OP) hydrolyser and an antioxidant bioscavenger enzyme. IC50 values were determined in the range of 0.123-1.212 mM.
Anahtar kelimeler
Atıf için künye
AKBABA, Y., TURKES, C., POLAT, L., SOYUT, H., Şahin, E., MENZEK, A., Göksu, S., & Beydemir, S. (2013). Synthesis and paroxonase activities of novel bromophenols. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 28(5), 1073–1079. https://doi.org/10.3109/14756366.2012.715287
BibTeX
@article{akbaba2013-66661,
author = {AKBABA, Yusuf and TURKES, Cuneyt and POLAT, Leyla and SOYUT, Hakan and Şahin, Ertan and MENZEK, Abdullah and Göksu, Süleyman and Beydemir, Sukru},
title = {Synthesis and paroxonase activities of novel bromophenols},
journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
year = {2013},
volume = {28},
number = {5},
pages = {1073--1079},
issn = {1475-6366},
doi = {10.3109/14756366.2012.715287},
url = {https://akademik.atauni.edu.tr/yayinlar/66661-synthesis-and-paroxonase-activities-of-novel-bromophenols}
}