Synthesis of Bis-spiro Cyclopropanes Based on Meldrum's Acid by Milling
Özet
Reaction of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid) with various solid aldehydes in the presence of cyanogen bromide and solid sodium ethoxide (EtONa) leads to the selective and efficient formation of bis-spiro cyclopropanes based on Meldrum's acid at the range of 0 degrees C to room temperature. The products were obtained in good to excellent yields. Structure elucidation is carried out by H-1 NMR, C-13 NMR, FT-IR spectroscopy, mass analyses and X-ray crystallography techniques. A possible mechanism for the formation of products is also discussed under solvent-free condition.
Atıf için künye
Kashani, E., Pesyan, N. N., Tunc, T., & Şahin, E. (2015). Synthesis of Bis-spiro Cyclopropanes Based on Meldrum's Acid by Milling. JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 62(3), 249–256. https://doi.org/10.1002/jccs.201400320
BibTeX
@article{kashani2015-66623,
author = {Kashani, Elmira and Pesyan, Nader Noroozi and Tunc, Tuncay and Şahin, Ertan},
title = {Synthesis of Bis-spiro Cyclopropanes Based on Meldrum's Acid by Milling},
journal = {JOURNAL OF THE CHINESE CHEMICAL SOCIETY},
year = {2015},
volume = {62},
number = {3},
pages = {249--256},
issn = {0009-4536},
doi = {10.1002/jccs.201400320},
url = {https://akademik.atauni.edu.tr/yayinlar/66623-synthesis-of-bis-spiro-cyclopropanes-based-on-meldrums-acid-by-milling}
}