Synthesis, characterization and anti-microbial evaluation of Cu(II), Ni(II), Pt(II) and Pd(II) sulfonylhydrazone complexes; 2D-QSAR analysis of Ni(II) complexes of sulfonylhydrazone derivatives
Özet
Copper(II), nickel(II), platinum(II) and palladium(II) complexes with 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) derived from propanesulfonic acid-1 -methylhydrazide (psmh) were synthesized, their structure were identified, and antimicrobial activity of the compounds was screened against three Gram-positive and three Gram-negative bacteria. The results of antimicrobial studies indicate that Pt(II) and Pd(II) complexes showed the most activity against all bacteria. The crystal structure of 2-hydroxy-1-naphthaldehyde-N-methylpropanesulfonylhydrazone (nafpsmh) was also investigated by X-ray analysis. A series of Ni(II) sulfonyl hydrazone complexes (1-33) was synthesized and tested in vitro against Escherichia coli and Staphylococcus aureus. Their antimicrobial activities were used in the QSAR analysis. Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO-LUMO energy gap play key roles in the antimicrobial activity. (c) 2013 Elsevier B.V. All rights reserved.
Atıf için künye
ÖZBEK, N., Alyar, S., ALYAR, H., Şahin, E., & KARACAN, N. (2013). Synthesis, characterization and anti-microbial evaluation of Cu(II), Ni(II), Pt(II) and Pd(II) sulfonylhydrazone complexes; 2D-QSAR analysis of Ni(II) complexes of sulfonylhydrazone derivatives. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 108, 123–132. https://doi.org/10.1016/j.saa.2013.01.005
BibTeX
@article{ozbek2013-66617,
author = {ÖZBEK, NESLİHAN and Alyar, Saliha and ALYAR, HAMİT and Şahin, Ertan and KARACAN, NURCAN},
title = {Synthesis, characterization and anti-microbial evaluation of Cu(II), Ni(II), Pt(II) and Pd(II) sulfonylhydrazone complexes; 2D-QSAR analysis of Ni(II) complexes of sulfonylhydrazone derivatives},
journal = {Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy},
year = {2013},
volume = {108},
pages = {123--132},
issn = {1386-1425},
doi = {10.1016/j.saa.2013.01.005},
url = {https://akademik.atauni.edu.tr/yayinlar/66617-synthesis-characterization-and-anti-microbial-evaluation-of-cuii-niii-ptii-and}
}