New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton

DENGİZ, ÇAĞATAY; Ozcan, Sevil; Şahin, Ertan; Balci, Metin

doi:10.1055/s-0029-1218673

Makale Tam Makale Uluslararası 2010

New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton

ÇAĞATAY DENGİZ, Sevil Ozcan, Ertan Şahin, Metin Balci

Synthesis (Germany) Sayı 8 · ss. 1365–1370 · 01.04.2010

DOI ile aç

Özet

We hereby report a new synthetic methodology for construction of the 1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one skeleton. 2-(2-Carboxyethyl)benzoic acid was converted into the corresponding bis(acyl azide). Curtius rearrangement of the diazide followed by reaction with alcohols provided diurethane derivatives. Ring-closure reaction of the diurethanes with base resulted in formation of the 1,3-benzodiazepin-2-one skeleton.

Anahtar kelimeler

ACID CHEMISTRY Acyl azide Curtius rearrangement isocyanate urethanes benzodiazepinone SELENIUM-ASSISTED CARBONYLATION CYCLIC UREAS BENZODIAZEPINE

Atıf için künye

DENGİZ, Ç., Ozcan, S., Şahin, E., & Balci, M. (2010). New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton. Synthesis (Germany)(8), 1365–1370. https://doi.org/10.1055/s-0029-1218673

BibTeX

@article{dengiz2010-66587,
  author = {DENGİZ, ÇAĞATAY and Ozcan, Sevil and Şahin, Ertan and Balci, Metin},
  title = {New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton},
  journal = {Synthesis (Germany)},
  year = {2010},
  number = {8},
  pages = {1365--1370},
  issn = {0039-7881},
  doi = {10.1055/s-0029-1218673},
  url = {https://akademik.atauni.edu.tr/yayinlar/66587-new-synthetic-methodology-for-construction-of-the-1345-tetrahydro-2h-13}
}