Furo- and thieno-fused 1,3-diazepine-4,6-diones
Özet
We report the first preparation of furo- and thieno-fused 1,3-diazepine-4,6-dione derivatives starting from ethyl 2-(2-methoxy-2-oxoethyl)-3-furancarboxylate and -thiophencarboxylate. The ester functionalities connected to the hetero-ring were converted regiospecifically into the desired amides. The ester groups attached to the methylene unit were converted into isocyanates via Curtius rearrangement. The ring-closure reaction was performed in the presence of lithium bis(trimethylsilyl)amide at room temperature to give furo- and thieno-fused diazepinone derivatives. (C) 2013 Elsevier Ltd. All rights reserved.
Atıf için künye
Ozer, M. S., Koza, G., Şahin, E., & Balci, M. (2013). Furo- and thieno-fused 1,3-diazepine-4,6-diones. Tetrahedron Letters, 54(48), 6553–6556. https://doi.org/10.1016/j.tetlet.2013.09.103
BibTeX
@article{ozer2013-66569,
author = {Ozer, Merve Sinem and Koza, Gani and Şahin, Ertan and Balci, Metin},
title = {Furo- and thieno-fused 1,3-diazepine-4,6-diones},
journal = {Tetrahedron Letters},
year = {2013},
volume = {54},
number = {48},
pages = {6553--6556},
issn = {0040-4039},
doi = {10.1016/j.tetlet.2013.09.103},
url = {https://akademik.atauni.edu.tr/yayinlar/66569-furo-and-thieno-fused-13-diazepine-46-diones}
}