Makale
Tam Makale
Uluslararası
2004
An efficient synthesis of substituted 4-aryl-3-cyano-2-amino thiophenes by a stepwise Gewald reaction
TURKISH JOURNAL OF CHEMISTRY
Cilt 28 · Sayı 4 · ss. 395–403 · 01.01.2004
Özet
The title compounds were efficiently synthesised starting from aryl methyl ketones in 3 steps. Knoevenagel condensation of aryl methyl ketones with malononitrile gave the corresponding crotonitriles (5a-f). Methyl groups of the crotonitriles (5a-f) were then efficiently brominated by refluxing and lightening the reaction media to give bromocrotonitriles (6a-f). The bromocrotonitriles (6a-f) were finally cyclised by treatment with NaSH to give the title compounds.
Anahtar kelimeler
aminothiophenes
bromocrotonitriles
substituted aminothiophenes
Atıf için künye
TUMER, F., Ekinci, D., ZILBEYAZ, K., & DEMIR, U. (2004). An efficient synthesis of substituted 4-aryl-3-cyano-2-amino thiophenes by a stepwise Gewald reaction. TURKISH JOURNAL OF CHEMISTRY, 28(4), 395–403.
BibTeX
@article{tumer2004-66298,
author = {TUMER, F and Ekinci, Duygu and ZILBEYAZ, K and DEMIR, U},
title = {An efficient synthesis of substituted 4-aryl-3-cyano-2-amino thiophenes by a stepwise Gewald reaction},
journal = {TURKISH JOURNAL OF CHEMISTRY},
year = {2004},
volume = {28},
number = {4},
pages = {395--403},
issn = {1010-7614},
url = {https://akademik.atauni.edu.tr/yayinlar/66298-an-efficient-synthesis-of-substituted-4-aryl-3-cyano-2-amino-thiophenes-by-a}
}