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Makale Tam Makale Uluslararası 2012

Effect of Sertraline in Indomethacin-Induced Gastric Mucosal Damage

Fehmi Celebi, Ahmet Akbas, Mustafa Sağlam, Abdullah Kisaoglu, Hamit Hakan Alp

ASIAN JOURNAL OF CHEMISTRY Cilt 24 · Sayı 5 · ss. 1966–1970 · 01.05.2012

Özet

The antiulcerative effect of sertraline was investigated using an indomethacin-induced ulcer model in rats. After the macroscopic analyses, malondialdehyde and glutathione amounts and superoxide dismutase, glutathione-S-transferase and glutathione peroxidase enzyme activities were determined in stomach tissues. It is presumed that the sertraline has positive effect in the treatment of gastric mucosal damages and this effect may be related to the decrease of oxidative stress and activation of antioxidant mechanisms by sertraline. For clinical use of sertraline by this effect, more prospective randomized studies should be done.

Anahtar kelimeler

PATHOGENESIS stress Depression LESIONS ACID ANTIOXIDANTS Free radicals LIPID-PEROXIDATION antioxidant ULCER Rat EXTRACT oxidant Sertraline ANTIULCER ACTIVITY

Atıf için künye

Celebi, F., Akbas, A., Sağlam, M., Kisaoglu, A., & Alp, H. H. (2012). Effect of Sertraline in Indomethacin-Induced Gastric Mucosal Damage. ASIAN JOURNAL OF CHEMISTRY, 24(5), 1966–1970.

BibTeX 
@article{celebi2012-64162,
  author = {Celebi, Fehmi and Akbas, Ahmet and Sağlam, Mustafa and Kisaoglu, Abdullah and Alp, Hamit Hakan},
  title = {Effect of Sertraline in Indomethacin-Induced Gastric Mucosal Damage},
  journal = {ASIAN JOURNAL OF CHEMISTRY},
  year = {2012},
  volume = {24},
  number = {5},
  pages = {1966--1970},
  issn = {0970-7077},
  url = {https://akademik.atauni.edu.tr/yayinlar/64162-effect-of-sertraline-in-indomethacin-induced-gastric-mucosal-damage}
}