The anti-genotoxic effect of some lichenic acids
Özet
Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 mu gmL(-1) of diffractic acid, lobaric acid and vulpinic acid, and 50 mu gmL(-1) of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.
Atıf için künye
Kizil, H. E., Ceker, S., ÇAPİK, O., & Ağar, G. (2018). The anti-genotoxic effect of some lichenic acids. JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA, 46(2), 227–231. https://doi.org/10.4038/jnsfsr.v46i2.8423
BibTeX
@article{kizil2018-61006,
author = {Kizil, Hamit Emre and Ceker, Selcuk and ÇAPİK, Ozel and Ağar, Güleray},
title = {The anti-genotoxic effect of some lichenic acids},
journal = {JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA},
year = {2018},
volume = {46},
number = {2},
pages = {227--231},
issn = {1391-4588},
doi = {10.4038/jnsfsr.v46i2.8423},
url = {https://akademik.atauni.edu.tr/yayinlar/61006-the-anti-genotoxic-effect-of-some-lichenic-acids}
}