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Makale Tam Makale Uluslararası 2015

Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays

Filiz Aygun ERTURK, Murat Aydın, Burcu SIGMAZ, Mahmut Sinan Taşpınar, Esra Arslan Yüksel, Güleray Ağar, Semra YAGCI

Environmental Science and Pollution Research Cilt 22 · Sayı 23 · ss. 18601–18606 · 01.12.2015
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Özet

Arsenic is a well-known toxic substance on the living organisms. However, limited efforts have been made to study its DNA methylation, genomic instability, and long terminal repeat (LTR) retrotransposon polymorphism causing properties in different crops. In the present study, effects of As2O3 (arsenic trioxide) on LTR retrotransposon polymorphism and DNA methylation as well as DNA damage in Zea mays seedlings were investigated. The results showed that all of arsenic doses caused a decreasing genomic template stability (GTS) and an increasing Random Amplified Polymorphic DNAs (RAPDs) profile changes (DNA damage). In addition, increasing DNA methylation and LTR retrotransposon polymorphism characterized a model to explain the epigenetically changes in the gene expression were also found. The results of this experiment have clearly shown that arsenic has epigenetic effect as well as its genotoxic effect. Especially, the increasing of polymorphism of some LTR retrotransposon under arsenic stress may be a part of the defense system against the stress.

Anahtar kelimeler

IN-VITRO DAMAGE toxicity EXPOSURE INDUCED OXIDATIVE STRESS RESPONSES As2O3 Zea mays DNA METHYLATION PROMOTER genomic instability hypermethylation LTR retrotransposons polymorphism SODIUM ARSENITE TOBACCO

Sürdürülebilir Kalkınma Amaçları

  • SKA 2: Açlığa Son

Atıf için künye

ERTURK, F. A., Aydın, M., SIGMAZ, B., Taşpınar, M. S., Arslan Yüksel, E., Ağar, G., & YAGCI, S. (2015). Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays. Environmental Science and Pollution Research, 22(23), 18601–18606. https://doi.org/10.1007/s11356-015-5426-2

BibTeX 
@article{erturk2015-60985,
  author = {ERTURK, Filiz Aygun and Aydın, Murat and SIGMAZ, Burcu and Taşpınar, Mahmut Sinan and Arslan Yüksel, Esra and Ağar, Güleray and YAGCI, Semra},
  title = {Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays},
  journal = {Environmental Science and Pollution Research},
  year = {2015},
  volume = {22},
  number = {23},
  pages = {18601--18606},
  issn = {0944-1344},
  doi = {10.1007/s11356-015-5426-2},
  url = {https://akademik.atauni.edu.tr/yayinlar/60985-effects-of-as2o3-on-dna-methylation-genomic-instability-and-ltr-retrotransposon}
}