PROTECTIVE ROLE OF TWO LICHENS IN HUMAN LYMPHOCYTES IN VITRO
Özet
In this study, the antagonistic effects of methanol extracts of Rhizoplaca chrysoleuca (RME) and Lecanora muralis (LME) were studied against effects of aflatoxin B-1 (AFB(1))-induced oxidative stress and genotoxicity in human lymphocytes in vitro. Results showed that 5 and 10 mu M concentrations of aflatoxin B-1 increased the frequencies of sister chromatid exchange (SCE), micronuclei (MN) and malondialdehyde (MDA) level, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities decreased. However, when 5 and 10 mu g/ml concentrations of LME and RME were added to AFB(1), the frequencies of SCE, MN and MDA level decreased but SOD and GPx activities increased. The results of this experiment have clearly shown that LME and RME have strong antioxidative and antigenotoxic effects, and may play a role in the anti-genotoxic activity mechanisms.
Atıf için künye
Alpsoy, L., Aslan, A., KOTAN, E., Ağar, G., & Anar, M. (2011). PROTECTIVE ROLE OF TWO LICHENS IN HUMAN LYMPHOCYTES IN VITRO. FRESENIUS ENVIRONMENTAL BULLETIN, 20(7), 1661–1666.
BibTeX
@article{alpsoy2011-60950,
author = {Alpsoy, Lokman and Aslan, Ali and KOTAN, Elif and Ağar, Güleray and Anar, Mustafa},
title = {PROTECTIVE ROLE OF TWO LICHENS IN HUMAN LYMPHOCYTES IN VITRO},
journal = {FRESENIUS ENVIRONMENTAL BULLETIN},
year = {2011},
volume = {20},
number = {7},
pages = {1661--1666},
issn = {1018-4619},
url = {https://akademik.atauni.edu.tr/yayinlar/60950-protective-role-of-two-lichens-in-human-lymphocytes-in-vitro}
}