Solid lipid nanoparticles loaded with lipoyl-memantine codrug: Preparation and characterization
Özet
Solid lipid nanoparticles (SLNs) are considered very attractive drug-delivery systems (DDS) able to enhance the efficacy of some therapeutic agents in several pathologies difficult to treat in a conventional way. Starting from these evidences, this study describes the preparation, physicochemical characterization, release, and in vitro cytotoxicity of stealth SLNs as innovative approach to improve solubility and absorption through the gastrointestinal tract of lipoyl-memantine (LA-MEM), a potential anti-Alzheimer codrug.
Anahtar kelimeler
Atıf için künye
LASERRA, S., BASIT, A., SOZIO, P., MARINELLI, L., FORNASARI, E., CACCIATORE, I., CIULLA, M., Türkez, H., Geyikoğlu, F., & DI STEFANO, A. (2015). Solid lipid nanoparticles loaded with lipoyl-memantine codrug: Preparation and characterization. International Journal of Pharmaceutics, 485, 183–191. https://doi.org/10.1016/j.ijpharm.2015.03.001
BibTeX
@article{laserra2015-59301,
author = {LASERRA, Sara and BASIT, Abdul and SOZIO, Piera and MARINELLI, Lisa and FORNASARI, Erika and CACCIATORE, Ivana and CIULLA, Michele and Türkez, Hasan and Geyikoğlu, Fatime and DI STEFANO, Antonio},
title = {Solid lipid nanoparticles loaded with lipoyl-memantine codrug: Preparation and characterization},
journal = {International Journal of Pharmaceutics},
year = {2015},
volume = {485},
pages = {183--191},
issn = {0378-5173},
doi = {10.1016/j.ijpharm.2015.03.001},
url = {https://akademik.atauni.edu.tr/yayinlar/59301-solid-lipid-nanoparticles-loaded-with-lipoyl-memantine-codrug-preparation-and}
}