Production of (R)-3 '-fluorophenylethan-1-ol by Trichothecium roseum isolate in a laboratory scale bioreactor
Özet
BACKGROUND: Enantiomerically pure, fluorinated compounds play an important role in medicinal chemistry. Trichothecium roseum strains were isolated for the production of (R)-3'-fluorophenylethan-1-ol. Biocatalytic production of optically active (R)3'-fluorophenylethan-1-ol was achieved by asymmetric reduction of 3'-fluoroacetophenone in a batch culture of Trichothecium roseum using ram horn peptone (RHP). The reaction conditions (pH, temperature and agitation) required to improve the conversion of 3'-fluoroacetophenone and enantiomeric excess (ee) of (R)-3'-fluorophenylethan-1-ol were studied.
Atıf için künye
Kurbanoğlu, E. B., Taşkın, M., Zilbeyaz, K., & Kurbanoglu, N. I. (2009). Production of (R)-3 '-fluorophenylethan-1-ol by Trichothecium roseum isolate in a laboratory scale bioreactor. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 84(10), 1474–1479. https://doi.org/10.1002/jctb.2204
BibTeX
@article{kurbanoglu2009-59221,
author = {Kurbanoğlu, Esabi Başaran and Taşkın, Mesut and Zilbeyaz, K. and Kurbanoglu, N. I.},
title = {Production of (R)-3 '-fluorophenylethan-1-ol by Trichothecium roseum isolate in a laboratory scale bioreactor},
journal = {JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY},
year = {2009},
volume = {84},
number = {10},
pages = {1474--1479},
issn = {0268-2575},
doi = {10.1002/jctb.2204},
url = {https://akademik.atauni.edu.tr/yayinlar/59221-production-of-r-3-fluorophenylethan-1-ol-by-trichothecium-roseum-isolate-in-a}
}