Acute and subacute toxic effects of CUMYL-4CN-BINACA on male albino rats.

Purpose: There is very little information about the

toxicological and pathological effects of synthetic cannabinoids, which have

cannabis-like properties. This study was carried out to histopathologically,

hematologically, and biochemically determine the toxic effects of acute and

subacute exposure to a novel synthetic cannabinoid 1-(4-cyanobutyl)-N-(2-phenylpropan-2-yl)indazole-3-carboxamide

in internal organs of adult male rats. <o:p></o:p>

Methods: The cannabinoid was injected

intraperitoneally at three doses (0.5, 1.0, and 2.0 mg/kg, body weight). The

cannabinoid was administered to acute groups for 2 days and to subacute groups

for 14 days. Observations were made for 14 days and various changes such as

mortality, injury, and illness were recorded daily. Hematological and biochemical

changes were evaluated and histopathological analyses in lung, liver, and

kidney tissues were also performed.<o:p></o:p>

Results: No mortality was observed. It was

observed that there were fluctuations in hematological and serum biochemical parameters.

Among the oxidative

stress parameters, significant decreases in superoxide dismutase, catalase levels

and significant increases in lipid peroxidation levels were determined. Serious

pathological changes such as necrosis, vacuolation, congestion, and fibrosis

were observed in the organs in a dose-dependent and time-dependent manner. It

was also found that the synthetic cannabinoid triggered apoptosis in internal

organs. The results demonstrated that the most affected organ by the

cannabinoid was the kidney. <o:p></o:p>

Conclusion: This study showed for the first time that

CUMYL-4CN-BINACA adversely affects healthy male rats. It can be estimated that

the abuse of the cannabinoid may harm human health in the same way.<o:p></o:p>