Synthesis, Characterization and Antimicrobial Activities of Tetra-Paraben Substituted Monospiro Cyclotriphosphazenes
Özet
Cyclotriphosphazenes, N3P3Cl6, one of the most precious members of inorganic ring systems,
are deeply preferred in the design and development of new molecules having different
physical and chemical properties for using diverse applications depending on the side
groups replacing their chlorine atoms [1,2].
Parabens, belong member of esters of p-hydroxybenzoic acid, are used as the preservative
or antimicrobial agents against fungi, bacteria and yeast for pharmaceutical and cosmetic
industries. Besides, parabens derivative compounds also exhibit several biological
properties such as highly cytotoxic activity on cancer line and DNA interaction [3-5].
In this study, firstly, the mono-spiro 2-Mercaptoethanol that contains both a hard oxygen
donor and a soft sulfur donor derivative of cyclotriphosphazene was synthesized to use as
starting compound. Then, the reactions of this compound with methyl paraben, ethyl
paraben, and propyl paraben respectively were caried out for first time. All newly
synthesized compounds were purified and their structures were characterized with different
spectroscopies technique such as single crystal X-ray diffraction, mass spectrometry, 1H,
and 31P NMR spectroscopies. The antimicrobial activities of the all compounds were
investigated.
Atıf için künye
Kızılkaya Saltık, P., Şenkuytu, E., Baltacı, M. Ö., & Yenilmez Çiftçi, G. (2023). Synthesis, Characterization and Antimicrobial Activities of Tetra-Paraben Substituted Monospiro Cyclotriphosphazenes. 9 TH INTERNATIONAL BAU DRUG DESIGN CONGRESS, İstanbul (ss. 91).
BibTeX
@inproceedings{kizilkayasaltik2023-56974,
author = {Kızılkaya Saltık, Perihan and Şenkuytu, Elif and Baltacı, Mustafa Özkan and Yenilmez Çiftçi, Gönül},
title = {Synthesis, Characterization and Antimicrobial Activities of Tetra-Paraben Substituted Monospiro Cyclotriphosphazenes},
booktitle = {9 TH INTERNATIONAL BAU DRUG DESIGN CONGRESS},
address = {İstanbul},
year = {2023},
pages = {91},
url = {https://akademik.atauni.edu.tr/yayinlar/56974-synthesis-characterization-and-antimicrobial-activities-of-tetra-paraben}
}