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Makale Tam Makale Uluslararası 2020

Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy

Hadiseh Taheri, MEHMET ALTAY ÜNAL, Melike Sevim Bayrak, Cansu Gurcan, OKAN EKİM, Ahmet Ceylan, Zois Syrgiannis, Konstantinos C. Christoforidis, Susanna Bosi, Ozge Ozgenc, Manuel Jose Gomez, Mine Turktas Erken, ÇİĞDEM SOYDAL, Zafer Eroglu, Ceylan Verda Bitirim, Umut Cagin, FİKRET ARI, Asuman Ozen, Ozlem Kucuk, Lucia Gemma Delogu, Maurizio Prato, Onder Metin, Acelya Yilmazer

SMALL Cilt 16 · Sayı 10 · 01.03.2020
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Özet

Thanks to its photocatalytic property, graphitic carbon nitride (g-C3N4) is a promising candidate in various applications including nanomedicine. However, studies focusing on the suitability of g-C3N4 for cancer therapy are very limited and possible underlying molecular mechanisms are unknown. Here, it is demonstrated that photoexcitation of g-C3N4 can be used effectively in photodynamic therapy, without using any other carrier or additional photosensitizer. Upon light exposure, g-C3N4 treatment kills cancer cells, without the need of any other nanosystem or chemotherapeutic drug. The material is efficiently taken up by tumor cells in vitro. The transcriptome and proteome of g-C3N4 and light treated cells show activation in pathways related to both oxidative stress, cell death, and apoptosis which strongly suggests that only when combined with light exposure, g-C3N4 is able to kill cancer cells. Systemic administration of the mesoporous form results in elimination from urinary bladder without any systemic toxicity. Administration of the material significantly decreases tumor volume when combined with local light treatment. This study paves the way for the future use of not only g-C3N4 but also other 2D nanomaterials in cancer therapy.

Anahtar kelimeler

IMPACT DEGRADATION nanoparticles GENERATION GRAPHENE OXIDE GRAPHITIC CARBON NITRIDE NANOSHEETS 2D materials antitumor activity omic approaches photodynamic therapy QUANTUM DOTS CELLULAR UPTAKE PHOTOSENSITIZERS

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Taheri, H., ÜNAL, M. A., Sevim Bayrak, M., Gurcan, C., EKİM, O., Ceylan, A., Syrgiannis, Z., Christoforidis, K. C., Bosi, S., Ozgenc, O., Gomez, M. J., Turktas Erken, M., SOYDAL, Ç., Eroglu, Z., Bitirim, C. V., Cagin, U., ARI, F., Ozen, A., Kucuk, O., … Yilmazer, A. (2020). Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy. SMALL, 16(10). https://doi.org/10.1002/smll.201904619

BibTeX 
@article{taheri2020-56574,
  author = {Taheri, Hadiseh and ÜNAL, MEHMET ALTAY and Sevim Bayrak, Melike and Gurcan, Cansu and EKİM, OKAN and Ceylan, Ahmet and Syrgiannis, Zois and Christoforidis, Konstantinos C. and Bosi, Susanna and Ozgenc, Ozge and Gomez, Manuel Jose and Turktas Erken, Mine and SOYDAL, ÇİĞDEM and Eroglu, Zafer and Bitirim, Ceylan Verda and Cagin, Umut and ARI, FİKRET and Ozen, Asuman and Kucuk, Ozlem and Delogu, Lucia Gemma and Prato, Maurizio and Metin, Onder and Yilmazer, Acelya},
  title = {Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy},
  journal = {SMALL},
  year = {2020},
  volume = {16},
  number = {10},
  issn = {1613-6810},
  doi = {10.1002/smll.201904619},
  url = {https://akademik.atauni.edu.tr/yayinlar/56574-photocatalytically-active-graphitic-carbon-nitride-as-an-effective-and-safe-2d}
}