Gold Nanoparticles and Reduced Graphene Oxide-Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment
Özet
AuNPs and AuNPs/RGO composites were engineered as drug delivery nanoplatforms to efficiently deliver the anti-cancer drug to MCF-7 breast cancer cells. The anti-cancer drug, mitoxantrone (MTX), was tethered to the gold nanoparticles via a 3-mercaptopropionic acid (MPA) spacer and an acid-cleavable amid bond (SMTX-AuNPs). Then, the surface of the RGO nanosheets were decorated with SMTX-AuNPs (SMTX-AuNPs/RGO). For comparison purposes, MPA functionalized nanoparticles (MPA-AuNPs) and their nanocomposites (MPA-AuNPs/RGO) were also prepared using the same procedure. The formation of the nanomaterials was verified by spectroscopic and morphological techniques. The drug delivery activity of materials on MCF-7 cells was investigated invitro using different methods. Our results demonstrate that SMTX-AuNPs have better activity on cancer cells than free MTX and SMTX-AuNPs/RGO. Further, contradicting previous studies, our findings suggest that the use of graphene-based materials for the covalent drug delivery systems need to be revisited.
Anahtar kelimeler
Sürdürülebilir Kalkınma Amaçları
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SKA 3: Sağlıklı Bireyler
Atıf için künye
Jafarızad, A., Aghanejad, A., Sevim Bayrak, M., Metin, O., Barar, J., Omıdı, Y., & Ekinci, D. (2017). Gold Nanoparticles and Reduced Graphene Oxide-Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment. ChemistrySelect, 2(23), 6663–6672. https://doi.org/10.1002/slct.201701178
BibTeX
@article{jafarizad2017-56568,
author = {Jafarızad, Abbas and Aghanejad, Ayuob and Sevim Bayrak, Melike and Metin, Onder and Barar, Jaleh and Omıdı, Yadollah and Ekinci, Duygu},
title = {Gold Nanoparticles and Reduced Graphene Oxide-Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment},
journal = {ChemistrySelect},
year = {2017},
volume = {2},
number = {23},
pages = {6663--6672},
issn = {2365-6549},
doi = {10.1002/slct.201701178},
url = {https://akademik.atauni.edu.tr/yayinlar/56568-gold-nanoparticles-and-reduced-graphene-oxide-gold-nanoparticle-composite}
}