Acetylcholinesterase Inhibitory Properties of Some Benzoic Acid Derivatives
Özet
Acetylcholinesterase (AChE) hydrolyses the neurotransmitter acetylcholine to acetic acid and choline. AChE inhibitors are used in treatment of several neurodegeneartive disorder and Alzheimer's disease. In the present study, inhibition of AChE with some benzoic acid derivatives were investigated. 3-Chloro-benzoic acid (1), 2-hydroxy-5-sulfobenzoic acid (2), 2-(sulfooxy) benzoic acid (3), 2-hydroxybenzoic acid (4), 2,3-dimethoxybenzoic (5), and 3,4,5-trimethoxybenzoic (6) were calculated IC50 values AChE enzyme. Kinetic investigations showed that similarly to AChE inhibitors. Benzoic acid derivatives (1-6) investigated are encouraging agents which may be used as lead molecules in order to derivative novel AChE inhibitors that might be useful in medical applications.
Atıf için künye
Karaman, M., Kılıç, D., Ünver, Y., Senturk, M., Aşkın, H., & Küfrevioğlu, Ö. İ. (2016). Acetylcholinesterase Inhibitory Properties of Some Benzoic Acid Derivatives. International Conference on Advances in Natural and Applied Sciences (ICANAS), Antalya. https://doi.org/10.1063/1.4945928
BibTeX
@inproceedings{karaman2016-56340,
author = {Karaman, Melike and Kılıç, Deryanur and Ünver, Yağmur and Senturk, Murat and Aşkın, Hakan and Küfrevioğlu, Ömer İrfan},
title = {Acetylcholinesterase Inhibitory Properties of Some Benzoic Acid Derivatives},
booktitle = {International Conference on Advances in Natural and Applied Sciences (ICANAS)},
address = {Antalya},
year = {2016},
doi = {10.1063/1.4945928},
url = {https://akademik.atauni.edu.tr/yayinlar/56340-acetylcholinesterase-inhibitory-properties-of-some-benzoic-acid-derivatives}
}