Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes

Dalkilic, Oguzhan; Turbedaroglu, Ozge; Lafzi, Ferruh; Kılıç, Haydar

doi:10.1021/acs.joc.3c01122

Makale Tam Makale Uluslararası 2023

Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes

Oguzhan Dalkilic, Ozge Turbedaroglu, Ferruh Lafzi, Haydar Kılıç

JOURNAL OF ORGANIC CHEMISTRY Cilt 88 · Sayı 16 · ss. 11834–11846 · 18.08.2023

DOI ile aç

Özet

Alkylated imidazopyridines are crucial structures formedicinalchemistry. Here, an efficient method for the C3-H alkylationof imidazopyridines was devised. Under Lewis acid-catalyzed conditions,reactions of imidazopyridines with different donor-acceptorcyclopropanes were carried out. Finally, 1,3-bisfunctionalizaton ofdonor-acceptor cyclopropanes was performed. In addition, synthesizedC3-alkylated imidazopyridines are amenable for diverse synthetic applications.

Atıf için künye

Dalkilic, O., Turbedaroglu, O., Lafzi, F., & Kılıç, H. (2023). Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes. JOURNAL OF ORGANIC CHEMISTRY, 88(16), 11834–11846. https://doi.org/10.1021/acs.joc.3c01122

BibTeX

@article{dalkilic2023-55550,
  author = {Dalkilic, Oguzhan and Turbedaroglu, Ozge and Lafzi, Ferruh and Kılıç, Haydar},
  title = {Regioselective C3-H Alkylation of Imidazopyridines with Donor-Acceptor Cyclopropanes},
  journal = {JOURNAL OF ORGANIC CHEMISTRY},
  year = {2023},
  volume = {88},
  number = {16},
  pages = {11834--11846},
  issn = {0022-3263},
  doi = {10.1021/acs.joc.3c01122},
  url = {https://akademik.atauni.edu.tr/yayinlar/55550-regioselective-c3-h-alkylation-of-imidazopyridines-with-donor-acceptor}
}