Rapid Mechanochemical Ring-Opening and 1,3-Bisfunctionalization of Donor-Acceptor Cyclopropanes: Regioselective C(sp2)-H Alkylation of Coumaran and Chromane
Özet
Regioselective alkylation of 2,3-dihydrobenzofuran (coumaran) and chromane was accomplished through the ring-opening of donor-acceptor cyclopropanes (DACs) under mechanochemical conditions. The developed mechanochemical protocol efficiently promotes the ring-opening of DACs. Importantly, it enabled the first mechanochemical 1,3-bisfunctionalization of DACs using a range of electrophiles, furnishing the target products in high yields and significantly reducing reaction times.
Atıf için künye
Atis, S., Lafzi, F., & Kılıç, H. (2025). Rapid Mechanochemical Ring-Opening and 1,3-Bisfunctionalization of Donor-Acceptor Cyclopropanes: Regioselective C(sp2)-H Alkylation of Coumaran and Chromane. JOURNAL OF ORGANIC CHEMISTRY, 90(41), 14408–14414. https://doi.org/10.1021/acs.joc.5c01198
BibTeX
@article{atis2025-55547,
author = {Atis, Sumeyye and Lafzi, Ferruh and Kılıç, Haydar},
title = {Rapid Mechanochemical Ring-Opening and 1,3-Bisfunctionalization of Donor-Acceptor Cyclopropanes: Regioselective C(sp2)-H Alkylation of Coumaran and Chromane},
journal = {JOURNAL OF ORGANIC CHEMISTRY},
year = {2025},
volume = {90},
number = {41},
pages = {14408--14414},
issn = {0022-3263},
doi = {10.1021/acs.joc.5c01198},
url = {https://akademik.atauni.edu.tr/yayinlar/55547-rapid-mechanochemical-ring-opening-and-13-bisfunctionalization-of-donor-acceptor}
}