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Makale Tam Makale Uluslararası 2019

The Reaction of Donor-Acceptor Cyclopropanes with 4,7-Dihydroindole: A New Protocol for the Synthesis of Divergent C2-Alkylated Indoles

Haydar Kılıç, Oguzhan DALKILIC

ChemistrySelect Cilt 4 · Sayı 13 · ss. 3737–3740 · 09.04.2019
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Özet

Nucleophilic ring opening reactions of donor-acceptor cyclopropanes with 4,7-dihydroindole (1 a) were described. A series of dimethyl 2-(2-(1H-indol-2-yl)-2-arylethyl)malonates were synthesized by using Ytterbium(III) trifluoromethanesulfonate as the catalyst for the first time in good to excellent yields. This study is also the first example for the reaction of donor-acceptor cyclopropanes with 4,7-dihydroindole. The obtained products are amenable to purposive elaborations. The synthesized compounds were characterized by using H-1 NMR, C-13 NMR and High Resolution Mass Spectroscopy (HRMS) techniques.

Anahtar kelimeler

ACID Indole 4 7-Dihydroindole Donor-Acceptor Cyclopropane p-Benzoquinone Ytterbium(III) trifluoromethanesulfonate FRIEDEL-CRAFTS ALKYLATION DIRECT C2 ARYLATION

Atıf için künye

Kılıç, H., & DALKILIC, O. (2019). The Reaction of Donor-Acceptor Cyclopropanes with 4,7-Dihydroindole: A New Protocol for the Synthesis of Divergent C2-Alkylated Indoles. ChemistrySelect, 4(13), 3737–3740. https://doi.org/10.1002/slct.201900268

BibTeX 
@article{kilic2019-55531,
  author = {Kılıç, Haydar and DALKILIC, Oguzhan},
  title = {The Reaction of Donor-Acceptor Cyclopropanes with 4,7-Dihydroindole: A New Protocol for the Synthesis of Divergent C2-Alkylated Indoles},
  journal = {ChemistrySelect},
  year = {2019},
  volume = {4},
  number = {13},
  pages = {3737--3740},
  issn = {2365-6549},
  doi = {10.1002/slct.201900268},
  url = {https://akademik.atauni.edu.tr/yayinlar/55531-the-reaction-of-donor-acceptor-cyclopropanes-with-47-dihydroindole-a-new}
}